The Breakdown of Fructose

The Breakdown of Fructose First of all I would like to describe the term enzymes. Basically enzymes are protein which is used in the chemical reaction and they act as a catalyst in these reactions. Their function is to speed up the chemical reaction without using themselves. If they are not used as a catalyst in the reactions than the reaction speed would be very slow and in this way the products of the reactions will not come. So it is now clear that enzymes are very important in certain biochemical reactions which are taking place in our body and without these enzymes our body will not be able to perform these biochemical reactions and as a result we will not be able to continue our life. Enzymes are involved in the breakdown of fructose. Basically fructose is simple sugar that is present in our food like honey and fruits. Fructose is basically a carbohydrate which provides energy to our body. it is very important to mention that fructose do not gave energy to our body directly but certain enzymes are require to breakdown this fructose into simpler sugar and then into usable form of energy. The process of the breakdown of fructose is as follows: Firstly when fructose in enters in our body then initial catabolism of fructose is takes place in our body and this process is referred to as fructolysis. The cycle of fructose breakdown begins with the enzyme called fructokinase which is found in liver. This fructokinase will produce fructose 1- phosphate so this is the end of first step. In the next step another enzyme named aldolase B will convert the fructose 1-phosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde. These two products are used by the body in order to get energy so without these enzymes the body will not be able to carry out the breakdown of fructose and in this way our body will not be able to ingest the food containing fructose. (Seller et al., 1969) Explain how a deficiency in aldolase B can be responsible for hereditary fructose intolerance. First of all I would like to explain the term fructose intolerance. Fructose intolerance is basically a condition in which the person is not able to digest the sugar fructose. After taking fructose containing diet like honey or fruits the person with fructose intolerance may experience nausea, bloating, abdominal pain, diarrhea and vomiting etc. Basically mutation in Adolab gene leads to the hereditary fructose intolerance. This Aldolab is responsible for the formation of Aldolase B enzyme. As I already mention that this enzyme is present in Liver and causes the breakdown of fructose and thus convert this fructose into simpler sugar which is then used as a source of energy in our body. A deficiency in the enzyme Aldolase B may cause the accumulation of the fructose 1-phosphate in the liver cell, small intestine and kidney and thus make our body unable to convert the fructose into simpler sugars and as a result the sugar level of the body will fall and cause the formation of the toxic substance that damage our liver. This damage to the liver cell leads to the liver dysfunctions, hypoglycemia and hereditary fructose intolerance. (Gitzelmann et al., 1989) Explain the role of aldolase B in the breakdown of fructose. Aldolase B plays an important role in the carbohydrate metabolism like it catalyzes one of the major steps of the glycolytic-gluconeogenic pathway. Along with its importance in the glucose breakdown it is also very important in fructose metabolism and it is very important to mention that fructose metabolism is occurring mostly in the liver, renal cortex and small intestine. The action of mechanism of this enzyme is that when fructose is absorbed by our body it is than phosphorylated into fructose 1-phospahte by the action of fructokinase. Then in the next step Aldolase B catalyzes the fructose 1-phosphate and converts it into glyceraldehyde and DHAP. After this step another enzyme triose kinase convert this glyceraldehyde into glyceraldehyde 3-phosphate which is then used in glycolytic-gluconeogenic pathway and that can be modified to become either glucose or pyruvate. (Peanasky et al., 1958) Discuss the specific substrate acted on by aldolase B. Aldolase B is equally active toward the substrate F-l-P (Fructose-1-Phosphate). Fructose-1-phosphate is a derivative of fructose. It is generated by fructokinase which is present in liver. It is converted by aldolase B into glyceraldehyde and dihydroxyacetone phosphate. The action of the adolase B on the substrate can be explained with the help of following figure: A description CASE 2- MITOCHONDRIAL DISEASE Explain what would happen to the cells energy reserves if the interconversions of the Cori cycle occurred and remained within a single cell. If interconversion of the coricycle occurred within the single cell then it would cause the futile cycle. Basically in the futile cycle glucose is used by the cell and re synthesized at the cost of ATP and GTP hydrolysis. And loss of ATP during this futile cycle would be 4 and thats why the futile cycle is regarded as an uneconomical cycle. (Nelson et al., 2005). Construct a dynamic model to show the doctor why the citric acid cycle is central to aerobic metabolism. The citric acid cycle can be regarded as an important metabolic center of the cell. It basically act as portal to the aerobic metabolism that has the ability to form acetyl group or dicarboxylic acid. The citric acid cycle is not only act as fuel for the cell but it is also a building block of many other molecules like amino acid, cholesterol, and porphyrin (the organic component of heme). There are infact different reactions like oxidation and reduction reactions which are takes place during Krebs cycle, and these reactions will result in the oxidation of an acetyl group to two molecules of carbon dioxide. The Kreb cycle was named after the person who introduce this cycle for the first time. Different biochemical changes are noticed during Krebs cycle which will enable the cell to store the energy for future use. The other name for this Kreb cycle is tricarboxylic or citric acid, cycle. ( (Lowenstein JM 1969). Explain the role of co-enzyme Q10 in ATP synthesis. First of all I would like to give a brief introduction of Co-enzyme Q10. Co-enzyme Q10 is basically a vitamin like substance which is present in every cell and its purpose is to generate energy. And due to this property it is also called as Ubiquitous. It is necessary in energy production in the 70-100 trillion body cells. Basically the co-enzyme Q10 is required in order to convert the energy from carbohydrate and fats into Adenosine triphosphate (ATP), and this process of production of ATP is carryout in the inner mitochondrial membrane. The process is like first of all the electrons which are produced during the fatty acid and glucose metabolism, Co-enzyme Q10 accept these electrons and then converted them into electron acceptors. At the same time Co-enzyme Q10 transfer the proton outside the mitochondrial membrane and in this way cause the formation of a proton gradient across that membrane. The energy released when the protons flow back into the mitochondrial interior and in this way it is used to form ATP. (Tomono et al., 1986) Explain where in the citric acid cycle a hypothetical defect could occur that prevents an increased conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) in response to an increased energy need and how the products of the citric acid cycle are converted into ATP. Basically during the Krebs cycle, a small amount of energy is released in order to cause the formation of molecule of ATP. It is very important to mention that in fact four-carbon molecule(oxaloacetic acid) is again created after the formation of CO2 mainly through oxidation reactions that occur in the Electron Transport Chain therefore any defect in ETC will prevent the conversion of ADP to ATP. Basically a gradient is formed in the ETC which is used to produce the ATP and this ATP is generated when H+ ion move down to its concentration gradient by a special enzyme called ATP synthase so it is now clear to us that if there is any defect in Electron transport chain then this will prevent the conversion of ADP to ATP. The products of Citric acid cycle are converted into ATP with the help of Oxidative- phosphorylation which is taking place in mitochondria. The NADH and succinate which is the product of Krebs cycle are oxidized and this will release the energy. This energy will power the ATP synthase and this enzyme will facilitate the production of ATP. (Mitchell and Moyle 1967).

Examples from placement

Whilst on my placement, there was a girl starting school full time; named Megan. Megan was why and reluctant to Interact with the other children, I noticed this and sat down next to her. To make her feel more secure, I tried talking to her In a calm voice. When listening to her, I was showing Interest In what she was saying, by positive facial expressions I made sure I gave enough time for Megan to think about her answer and if she answered correctly, I praised her to effectively boost her self-esteem and make her feel valued.However, she asked to participate in an activity that wasn't available, I calmly said in a slow voice â€Å"you are not allowed to do that†. When she kept asking, I reinforced my previous statement, to help her understand the boundaries expected of her. After she told me what games she enjoyed, I asked if she wanted to join in with the other children. Whilst asking her, I showed her pictures of the activities. Megan asked toxin the play-doe group, so I se tup an area for her.I introduced Megan to some of the other children, so she would feel more comfortable and welcome within the group.. Throughout the day, I was making sure Mean's needs were being met, for example asking her If she needed the toilet. I felt Like Megan was at an age, where she can Independently ask for the toilet, but to be safe I asked anyway. I needed to make sure that when asking her. I spoke clearly, so she could fully understand what I was asking and she could reply appropriately.I also, needed to make sure that she knew where things were, so she felt confident going herself. So I didn't lower Mean's self-esteem, I spoke to her in an assertive tone, if I had spoken to her in an aggressive manner it would have made her feel uncomfortable talking to me. For example â€Å"Can you please help the other children clean up? During my placement, there was a three year old girl, named Victoria. Victoria and family had just moved from Russia. Her parents could speak lit tle English and Victoria none.Very shy and reluctantly, she sat in the corner, playing by herself. I decided to have 1-1 time with her, and try to build a trusting relationship. I knew she was shy because she turned her body away from me and wouldn't make eye contact with me. Violator was obviously upset leaving her parents and feeling left out from the other children. In order for Victoria to understand me I spoke In basic minting to the picture of the sandpit, because she didn't understand English and it made it easier for her to understand which activities I was saying.When I gain some for her trust, she started using eye contact and more body language. By rubbing her eyes, I sat down with her and slowly and calmly asked what was wrong. She looked at me and said â€Å"tired†. I had to have her explain to me in more detail, so I showed her pictures of a bed and of possible activities she would enjoy. I made sure that I gave her enough time to reply, without interrupting and waiting patiently, or this could sibyl lower her self-confidence.She regained eye contact and pointed to the jigsaw puzzle. I taught Victoria a few basic words in English, by pointing to the object and waiting for her to repeat the word after me in English. When she repeated the word, I made sure I had positive facial expressions and body language, and praised her when she said it correctly. It was important that I used non-verbal communication, because it would affect her emotionally, by boosting her self- confidence and self-esteem and she would comfortable talking to me.If I made no effort to acknowledge she didn't know English, this would lower her self-esteem and make her feel isolated within the setting, because she wouldn't feel comfortable coming to talk to me and make her feel like she couldn't trust me. This means, she would have trouble communicating and interacting with the other children, and she wouldn't be able to tell me any problems she has; because of the lack of trust. To build our relationship further, in return, Victoria can teach me some words/phrases in Russian. This will allow us to have conversations in her language and she can feel more comfortable.

Economic Globlization - 1286 Words

Capitalism and Economic Globalization In a perfect world there would be no hunger, no poverty, and no crime, but no such world will ever exist. There will always be suffering, hurt, anguish, and despair. Yet, shouldn’t we strive to provide a good future for all? This concept of the most amounts of good for the most amounts of people is call Utilitarianism. Contrary to popular belief, the United States doesn’t believe in such a state of being. Instead, through capitalism and economic globalization the United States has proven to believe in the exact opposite of utilitarianism. The United States has always been based on the principles of capitalism; however, the present economy is far from being the free enterprise system†¦show more content†¦Jeremy Bentham was his tutor that was well known for having created Utilitarianism. â€Å"Bentham’s mission in life was to reform law, government, and economics to make them serve the principle of utility, or the greatest happiness principle†. John Mill later wrote a book Utilitarianism after being the upholder for it’s theory and principles. He described it as the greatest happiness principle, is the ultimate principle of morality. So the way the United States is shaped we are far from that. The wealthy that are in power create a status quo in which no progress is made. The system is maintained by the ignorance of the lower classes and the wealth and power of the upper classes. In thus, we have the power elite creating a class system, creating racial and gender bias, destroying th ird world nations, and Americanizing the rest of the world. The outcome, well we’ll see†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ Holland is every conservative’s nightmare come true. Legal prostitution, coffee houses that sell weed to teens, give away free needles to drug users, euthanasia in hospitals. To us such policies represent a moral breakdown. In belief with Utilitarianism, Judge Frits Ruter believes that the greater the happiness the less unhappiness. Legalization allows the government much more flexibility than criminalization. For example, â€Å"prostitutes must undergo regular health examinations†. On result is an astonishingly low rate of AIDS infection: less than one percent, comparedShow MoreRelatedA Brief Note On Canada s Labour Force2534 Words   |  11 Pagescommunities but with the introduction of economic globalization, the trading of goods services is now done between neighbouring provinces, nations, and countries. Many different workplace sectors have been affected by econmic globalization and the one that will be focused on in this paper will be the retail sector. Canada’s retail workplace and the workers, who work in retail stores, have been transformed due to economic globalization in regards to economic integration and interdependence betweenRead More Diversity Essay901 Words   |  4 Pagesidentities. But the underlying culture still determines a lot of the emerging cultures the local focus is still present, and we have not yet reached a universal culture. At the end of the twentieth century the post-modern culture order, and the economic order have given lift , in the united states in particular, to a new form of identity. A global identity. Particularly the Northern states celebrate the transnational feeling, and the globalization of their citizens. Hispanic students speak EnglishRead MoreWhat Do You Understand by the Term Globalization3109 Words   |  13 Pagesis a word being most mentioned in our world today. Globalization has been defined with numerous and widely differing meanings dating back to 1870 as economic integration through trade, migration, capital flows and communication (Mann, 2005).Globalization has been defined with numerous and widely differing meanings dating back to 1870 as Economic integration through trade, migration, communication and Capital Flows (Mann, 2005).Tuy nhià ªn cho Ä‘á º ¿n nay, ngÆ °Ã¡ » i ta vá º «n chÆ °a thá »Æ' thá »â€˜ng nhá º ¥t vá »  khà ¡i niá »â€¡mRead MoreThe Role of Media in the Society9486 Words   |  38 PagesKNOWLEDGE LIKE EDUCATION ETC.MEDIA GIVES VOICES TO POOR PEOPLE. THAT WAY MEDIA PLAYS AN IMPORTANT ROLE IN SOCIETY. || monika18-Sep-2009 |In my opinion media has become a part of our day today life. Without it, it is hard to survive. In the era of globlization we need to know what is happenning. Around us and around the world , which can be only posssible when we get to know about it the right information and media play this role very sincerely. But some times it make a huge issue of a small matter which

Why Is Oklahoma Creating Jobs - 905 Words

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